What to do with the Depleted Mana Rune in Path of Exile 2

The Depleted Mana Rune is a rare endgame secret in Path of Exile 2 that can be transformed into the Infused Mana Rune by defeating the Uhtred boss and having a build with 10,000 Mana. This Infused Mana Rune can then be traded to Farrow for the Runeseeker's Call Runic Fork, a powerful Ezomyte Wand, and unlocks the spell The Stars Answer.

• GAME Path of Exile
• COMPANY Grinding Gear Games